Role of Exposure to Environmental Chemicals in the Developmental Basis of Reproductive Disease and Dysfunction

Jerrold J. Heindel

doi:10.1055/s-2006-944423

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2006; 24(3): 168-177
DOI: 10.1055/s-2006-944423

Published in 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Role of Exposure to Environmental Chemicals in the Developmental Basis of Reproductive Disease and Dysfunction

Jerrold J. Heindel¹

¹Scientific Program Administrator, Division of Extramural Research and Training, Cellular, Organs, and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, Department of Health and Human Service, Research Triangle Park, North Carolina

Abstract

ABSTRACT

There is a paradigm shift in science at present that indicates that the onset of many diseases, including reproductive diseases and dysfunctions, are already programmed in utero or in the early postnatal period. This new field is called the developmental basis of health and disease. Although focus has been on the role of in utero nutrition and its effects on subsequent adult-onset diseases, it is clear that exposure to environmental stressors/toxicants in utero or during early development can also increase susceptibility to disease later in life. The mechanism for this in utero and early developmental effect is thought to be altered epigenetic control of gene expression, which alters developmental programming and results in a tissue that may appear normal but is functionally compromised. Although this concept is still a hypothesis, this review addresses the current state of data relating to proving its importance and role in reproductive diseases. If the developmental basis of disease is shown to be true, then examination of the etiology of disease and prevention and intervention strategies will need to be modified to fit the new paradigm.

KEYWORDS

Development - environmental exposures - reproduction - transgenerational effects - epigenetics

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Referenzen

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Jerrold J HeindelPh.D.

Scientific Program Administrator, Division of Extramural Research and Training, Cellular, Organs, and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, Department of Health and Human Service

79 T.W. Alexander Drive, Building 4401 3rd Floor, Mail Drop: EC-23, Room 3413, Research Triangle Park, NC 27709

eMail: heindelj@niehs.nih.gov